Description
Human Fibronectin from Human Plasma
| Catalog number: | B2014151 |
| Lot number: | Batch Dependent |
| Expiration date: | Batch Dependent |
| Amount: | 0.5 mg |
| Molecular Weight: | 440 kDa |
| Supplied as: | Solution |
| Applications: | Cell adhesion, wound healing, ECM modeling |
| Storage: | -20C |
| Keywords: | Human Fibronectin |
| Grade: | Biotechnology grade; ultrapure water (18 Mcm), 0.22 m filtered |
Fibronectin is a high-molecular-weight glycoprotein found in plasma and the extracellular matrix, playing a pivotal role in cell adhesion, migration, and tissue repair. This human plasma-derived formulation is supplied as a solution and retains full biological activity for use in cell culture, wound healing models, and extracellular matrix (ECM) assembly studies.
Fibronectin interacts with integrins and other ECM components to regulate cellular behavior and matrix organization. It is widely used in coating substrates for cell attachment, studying mechanotransduction, and modeling tissue regeneration. This reagent supports applications in developmental biology, ophthalmology, dermatology, and bioengineering platforms.
Key Features:
- Human plasma-derived fibronectin, 440 kDa
- Supplied as a filtered solution for immediate use
- Validated for ECM modeling, wound healing, and cell adhesion assays
- Biotechnology grade; RUO designation
- Stored at -20C for optimal stability
Indication for Use:
This product is for Research Use Only. It is not intended for human or animal use, diagnostic procedures, or therapeutic applications.
References Related to Human Fibronectin
- Patten J, Wang K. Fibronectin in development and wound healing. Adv Drug Deliv Rev. 2021 Mar;170:353368.
- Singh P et al. Assembly of fibronectin extracellular matrix. Annu Rev Cell Dev Biol. 2010;26:397419.
- Retta SF et al. Purification of fibronectin from human plasma. Methods Mol Biol. 1999;96:119124.
- Ruoslahti E. Fibronectin. J Oral Pathol. 1981 Feb;10(1):313.
- Pietrocola G et al. Purification of Human Plasma/Cellular Fibronectin and Fragments. Methods Mol Biol. 2017;1627:309324.
- Akiyama SK, Yamada KM. Fibronectin. Adv Enzymol Relat Areas Mol Biol. 1987;59:157.
- Stasko T, De Villez RL. Fibronectin. Int J Dermatol. 1982 Mar;21(2):6874.
- Floyd BB et al. Fibronectin in human trabecular drainage channels. Invest Ophthalmol Vis Sci. 1985 Jun;26(6):797804.
- Mitrovi S et al. [Fibronectina multifunctional glycoprotein]. Srp Arh Celok Lek. 1995 JulAug;123(78):198201.
- Erickson HP. Stretching fibronectin. J Muscle Res Cell Motil. 2002;23(56):575580.
