-Defensin-5 (Human)

Description

-Defensin-5 (Human)

-Defensin-5 (HD-5) is a human antimicrobial peptide secreted by Paneth cells in the small intestine. It plays a critical role in mucosal immunity by neutralizing pathogens, modulating microbiota composition, and regulating inflammatory responses. This 32-residue peptide contains three disulfide bridges that stabilize its -sheet-rich structure, enabling potent activity against bacteria, fungi, and viruses.

Researchers use -Defensin-5 in studies of inflammatory bowel disease (IBD), Crohns pathology, gut barrier integrity, and innate immune signaling. It has been shown to suppress colon cancer growth via PI3K pathway inhibition, neutralize Clostridioides difficile toxins, and influence microbial sensing in Vibrio cholerae. Its expression is tightly regulated by microbial metabolites and bitter taste receptors, making it a valuable biomarker and therapeutic candidate in gastrointestinal and metabolic research.

This product is supplied as a highly pure synthetic peptide, rigorously validated for reproducibility in in vitro assays. It is intended for Research Use Only (RUO) and not for diagnostic or therapeutic applications.

Key Features:

• Human -Defensin-5 peptide with native disulfide bridge topology
• Validated for use in IBD, microbiome, and mucosal immunity research
• CAS : 798569-33-2; Molecular Mass: 3582.1 g/mol
• Supplied at 0.1 mg; stored at 20C
• RUO designation: not for clinical or therapeutic applications

Indication for Use:
This product is for Research Use Only (RUO). It is not intended for human or animal use, diagnostic procedures, or therapeutic applications.

References:
1: Yang E, Shen J. The roles and functions of Paneth cells in Crohns disease: A critical review Cell Prolif. 2021 Jan;54(1):e12958.
2: MKoma AE. Inflammatory Bowel Disease: Clinical Diagnosis and Surgical Treatment-Overview Medicina (Kaunas). 2022 Apr 21;58(5):567.
3: Luo G, Zhang J, Wang H, Sun Y, Cheng B, Xu Z, Zhang Y, Li H, Lu W, Nemeth E, Ganz T, Fang X. Human defensin-inspired discovery of peptidomimetic antibiotics Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2117283119.
4: Liszt KI, Wang Q, Farhadipour M, Segers A, Thijs T, Nys L, Deleus E, Van der Schueren B, Gerner C, Neuditschko B, Ceulemans LJ, Lannoo M, Tack J, Depoortere I. Human intestinal bitter taste receptors regulate innate immune responses and metabolic regulators in obesity J Clin Invest. 2022 Feb 1;132(3):e144828.
5: Sugi Y, Takahashi K, Kurihara K, Nakano K, Kobayakawa T, Nakata K, Tsuda M, Hanazawa S, Hosono A, Kaminogawa S. -Defensin 5 gene expression is regulated by gut microbial metabolites Biosci Biotechnol Biochem. 2017 Feb;81(2):242-248.
6: Williams AD, Korolkova OY, Sakwe AM, Geiger TM, James SD, Muldoon RL, Herline AJ, Goodwin JS, Izban MG, Washington MK, Smoot DT, Ballard BR, Gazouli M, MKoma AE. Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease PLoS One. 2017 Aug 17;12(8):e0179710.
7: Korbmacher M, Fischer S, Landenberger M, Papatheodorou P, Aktories K, Barth H. Human -Defensin-5 Efficiently Neutralizes Clostridioides difficile Toxins TcdA, TcdB, and CDT Front Pharmacol. 2020 Aug 12;11:1204.
8: Yasuda G, Kobayashi M, Kubota A, Narumi K, Furugen A, Saito Y, Satoh T, Suzuki N, Iseki K. Analysis of -Defensin 5 Secretion in Differentiated Caco-2 Cells: Comparison of Cell Bank Origin Biol Pharm Bull. 2021;44(2):275-278.
9: Liu Y, Xu T, Wang Q, Huang J, Zhu Y, Liu X, Liu R, Yang B, Zhou K. Vibrio cholerae senses human enteric -defensin 5 through a CarSR two-component system to promote bacterial pathogenicity Commun Biol. 2022 Jun 8;5(1):559.
10: Qiao Q, Bai R, Song W, Gao H, Zhang M, Lu J, Hong M, Zhang X, Sun P, Zhang Q, Zhao P. Human -defensin 5 suppressed colon cancer growth by targeting PI3K pathway Exp Cell Res. 2021 Oct 15;407(2):112809.