Description
Croton Oil (Highly Pure) Catalog Number: B2018055 (5 g)
| Catalog number: | B2018055 |
| Lot number: | Batch Dependent |
| Expiration Date: | Batch dependent |
| Amount: | 5 g |
| Molecular Weight or Concentration: | N/A |
| Supplied as: | Solution |
| Applications: | a molecular tool for various biochemical applications |
| Storage: | RT |
| Keywords: | N/A |
| Grade: | Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity>18 M-cm) and are filtered through 0.22 um. |
Croton Oil (Highly Pure) (Catalog B2018055, 5 g solution) is a highly refined extract derived from the seeds of *Croton tiglium* and is renowned for its potent irritant properties. As a molecular-grade reagent, it serves as a key tool in biochemical modeling, dermatological research, and immunological assay development. Storage at ambient temperature (RT) simplifies lab workflows, while maintaining integrity and activity across diverse applications.
In biochemical and immunological studies, Croton Oil is frequently employed to model inflammatory responses, simulate tissue irritation, or probe immune activation thresholds. Its effectiveness in generating controlled irritation makes it a standard reagent in studies of skin barrier dynamics, inflammation-mediated signaling pathways, and testing of anti-inflammatory compounds. The high degree of purity ensures consistent dosing and minimized technical variabilitycritical for reproducibility in multi-lab or time-separated experiments.
Croton Oil is also widely used in dermatological chemistry, especially in the formulation of phenol-croton peels. Its robust activity enhances exfoliation mechanisms, enabling the study of epidermal response and dermal regeneration under controlled in vitro conditions. When integrating this reagent into experimental workflows, researchers often start with micro-volumes and titrate exposure time to calibrate target effect sizes. Precise documentation of concentration, lot, and storage conditions helps align with SOPs and LIMS systems, promoting consistent data capture across studies.
Why researchers choose this product:
- Highly pure seed extractsuitable for reproducible inflammatory or irritation modeling
- Defined 5 g solution format streamlines assay setup and volumetric control
- Ambient (RT) storage offers flexibility and ease of handling
- Ideal for both basic inflammation studies and dermatological model systems
- Biotechnology-grade clarity and filtration support sensitive assay integration
This product is for research use only (RUO). It is not intended for diagnostic or therapeutic use.
References
- 1: Wambier CG, Lee KC, Soon SL, Sterling JB, Rullan PP, Landau M, Brody HJ; International Peeling Society. Advanced chemical peels: Phenol-croton oil peel J Am Acad Dermatol. 2019 Aug;81(2):327-336.
- 2: Bensimon RH. Croton oil peels Aesthet Surg J. 2008 Jan-Feb;28(1):33-45.
- 3: Kotler R. Croton oil peels Aesthet Surg J. 2008 Jul-Aug;28(4):470; author reply 470-1.
- 4: Bensimon RH. Chemical Peels Facial Plast Surg Clin North Am. 2023 Nov;31(4):475-494.
- 5: Atiyeh B, Oneisi A, Ghieh F. Medium-depth Trichloroacetic Acid and Deep Phenol-Croton Oil Chemical Peeling for Facial Rejuvenation: An Update J Craniofac Surg. 2021 Nov-Dec 01;32(8):e745-e750.
- 6: Soon SL, Wambier CG, Rullan PR, Sterling JB, Brody HJ, Lee KC, Kreyden OP, Landau M; International Peeling Society; International Peeling Society. Phenol-Croton Oil Chemical Peeling Induces Durable Improvement of Constitutional Periorbital Dark Circles Dermatol Surg. 2023 Apr 1;49(4):368-373.
- 7: Lemes BM, da Silva Justo A, Lin EM, Capote ACMO, Neves AKL, Machinski I, Pereira AV, Koga AY, Lipinski LC, Beltrame FL, Miot HA, Wambier CG. The effects of 35% trichloroacetic acid-Croton oil and 35% glycolic acid-Croton oil compared to 35% phenol-Croton oil Hetters very heavy formula for deep chemical peel J Am Acad Dermatol. 2022 Nov;87(5):1227-1229.
- 8: Cardoso FAMES, Moura RD, Pilar EFS, Moura ICG, Miot HA, da Costa A. Phenol-croton oil peel enhances type-1 and type-3 collagen amounts by stimulating SIRT-6 and SIRT-7 Int J Dermatol. 2022 Feb;61(2):e71-e74.
- 9: Cardoso FAMES, Pilar EFS, Moura ICG, de Melo CB, Pompeu VMA, Moura RD, Ramos-E-Silva M, da Costa A. Neocolagenesis by phenol-croton oil peel is independent from the MMP 1/MMP-2/JunB and p53 pathways J Cosmet Dermatol. 2022 Apr;21(4):1766-1769.
- 10: Arajo Monteiro P, Maccari Zelioli A, de Oliveira Sousa IM, Ruiz ALTG, Vendramini-Costa DB, Foglio MA, Carvalho JE. Chemical composition and antiproliferative activity of Croton campestris A.St.-Hil. essential oil Nat Prod Res. 2019 Feb;33(4):580-583.
